For decades, metformin has been the go-to treatment for type 2 diabetes, yet its exact mechanism was unclear. A new study from Baylor College of Medicine reveals that the brain plays a surprising role. Researchers found that metformin lowers blood sugar by acting on a protein called Rap1 in the ventromedial hypothalamus (VMH). In experiments, the drug activated specific neurons, reducing glucose levels even at very tiny doses when given directly into the brain. This discovery suggests metformin doesn’t only act on the liver and gut, but also the brain, opening possibilities for more precise diabetes treatments according to SciTech daily news.
Metformin’s Diabetes-Fighting Power Traced to the Brain
